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Antisperm Antibodies

Asthenospermia & Immune Infertility Treatment

Antisperm Antibodies

Antisperm antibodies arise when the body becomes sensitized to sperm, causing an immune system response that destroys the sperm. Normally, sperm is protected from the immune system by way of a special barrier in the testes.

Antibody Attacking Sperm
Testes Barrier

In men who have antisperm antibodies, this barrier has been broken, and the immune system is now able to recognize the unique antigen on sperm and subsequently attack them.

The presence of anti-sperm antibodies (ASA) is a cause of infertility in men and women. Antibodies against sperm can prevent their motility through the female reproductive tract or prevent the process of fertilization. It has been shown that both males and females can make antibodies that react with human sperm.

ASA Detection
ASA in Males: Seminal Plasma, Serum & Sperm Surface
ASA in Females: Blood & Cervical Mucus
40%
Unexplained Infertility Cases

In males, for example, ASA can be detected in seminal plasma and serum, and are also located on the surface of sperm, which cannot be detected in a routine semen analysis. The female may produce ASA, which may be found in circulating blood, or produced in the cervical mucus. ASA have usually been found in homosexual males and in cases of testicular trauma, varicocele, mumps or orchitis, spinal cord injury, congenital absence of the vas and vasectomy.

Risk Factors in Males

Homosexual males
Testicular trauma
Varicocele
Mumps or orchitis
Spinal cord injury
Congenital absence of the vas
Vasectomy

Risk Factors in Females

ASA in circulating blood
ASA produced in cervical mucus
Partner-specific immune response

How Antibodies Affect Sperm

Depending on where the antibodies are located, sperm can be affected in a variety of ways.

Antibodies on the Tail: Sperm tends to be immobilized or may clump together.

Antibodies on the Head: Prevent the sperm from properly binding to the egg, thereby preventing fertilization from taking place.

Sperm Antibody Locations - Head vs Tail

Antibody attachment locations on sperm — Head (prevents binding) vs Tail (causes immobilization)

In some instances, a woman's cervical mucus can also develop antibodies to her partner's sperm. It is believed that antisperm antibodies in the cervical mucus may account for as much as 40% of unexplained infertility in couples.

Cervical Mucus Antibodies

Homeopathic medicines will act very well in Antisperm antibodies, because ASA is an Autoimmune disorder.

Get Natural Treatment for Antisperm Antibodies

Dr. R.K. Singh offers effective homeopathic treatment for autoimmune infertility. Consult today for a personalized treatment plan.

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